Searchable abstracts of presentations at key conferences in endocrinology

ea0026p370 | Signal transduction | ECE2011

Distribution of 3-iodothyronamine and trace amine-associated receptors in mouse

Chiellini G , Erba P , Carnicelli V , Ghelardoni S , Frascarelli S , Zucchi R

Introduction: 3-Iodothyronamine (T1AM) is a novel endogenous relative of thyroid hormone able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors (TAAR). Metabolic, endocrine and cardiac effects of exogenous T1AM have been reported.Methods: We synthesized radiolabelled T1AM, [125I]-T1AM, and explored its distribution in different mouse organs after injection in the tail vein. The specificity of [<su...